I was searching around on the site, and I don't see where this topic has ever come up, so I thought I would mention a few things I've learned while driving our motorhome, and hopefully other can share their tidbits as well. When we purchased the first coach I was pretty nervous about driving it, and rightfully so it was much bigger than anything I had ever driven.
Here are my short list of tips:
On mine if you're in the drivers seat and aim the mirrors down so you can see the side marker lights, the motorhome will pivot where you see the side marker light when backing up. You should test this as it probably does not apply to all motorhomes. It's about the same if I open the window and look back at the marker light.
Along with that make sure you look up and down when backing up and check all clearances when traveling, these motorhomes can be pretty tall. It's a good idea to print your max height and stick it in view of the driver, so you can always have it to check against when you see a clearance sign.
When your at a red light turning left on a multi-lane road, make sure there are no cars tight on the right of you as your tail can swing wide right and take one out.
Keep your eyes way down the road, and be ready for anything.